Head of the laboratory- doctor of clinical laboratory diagnostics, Olga S. Kalmykova.
The Laboratory for the Immunological Safety of Transfusions performs a complex of clinical and diagnostic studies in accordance with the current regulatory documents, instructions and methods. The laboratory functions as part of the Division of Transfusiology.
The laboratory performs a multitude of immunohematological studies for patients of the NMRC for Hematology’s clinics and donors. The laboratory is also responsible for the quality control of the received blood components.
Laboratory staff are highly qualified specialists with extensive work experience.
The list of analyzes carried out in the laboratory:
- clinical blood tests of donors (primary determination of blood group and Kell antigen, general clinical blood test with leukocyte formula, thrombogram, determination of ESR, hemoglobin amount, Duke bleeding time);
- biochemical studies (determination of alanine aminotransferase, total protein, protein fractions);
- immunohematological studies (determination of the blood group AB0, Rh, Kell, phenotype; test for compatibility before transfusion of erythrocyte-containing media; determination of compatible donor-recipient pairs for platelet transfusions; determination of anti-erythrocyte antibodies (indirect Coombs test); determination of the titer of natural isohemagglutinins; determination of cold erythroagglutinins; direct Coombs test; immunological analysis of post-transfusion reactions)
- medical examination of blood donors in conditions of departure;
- quality control of blood components;
- advisory reception of blood samples from other health facilities in the event of controversial cases and difficulties in laboratory diagnostics associated with the patient's condition.
Objective: Improving the quality of laboratory tests of donor blood to ensure the efficiency and safety of transfusion of blood components. Improving the quality of immunohematological blood tests in donors and recipients to ensure the immunological safety of transfusion of blood components. Thanks to the work of the laboratory, constant dynamic monitoring of the health of the donor and careful monitoring of the received blood products and its components are carried out.
KEY EMPLOYEES
Igor V. Dubinkin — leading specialist, Candidate of Biological Sciences. Igor Dubinkin graduated from the Faculty of Biology of the Gorky State University named after N. I. Lobachevsky with a red diploma in the specialty of a biologist-biophysicist, teacher in 1985. He received his specialization at the Department of Molecular Biology and Immunology. He began his career in August 1985 as a senior laboratory assistant at the Gorky Research Institute of Epidemiology and Microbiology. From 1986 to 1990, he was a research intern at the All-Union Cancer Research Center named after N. N. Blokhin, where he performed and defended, under the guidance of Professor A. Y. Baryshnikov, a dissertation for the degree of Candidate of Biological Sciences on the topic, "Monoclonal antibodies to the line of unrestricted human antigens." From 1992 to 2005, he was a leading researcher of the Biotechnology Laboratory of the Immunogenetics Department of the NMRC for Hematology Institute of Immunology of the Federal Medical and Biological Agency of Russia. Since 2005, he has been working at the NMRC for Hematology in the Laboratory for Standardization of Blood Groups. Currently, he is the head of the Transfusion Biotechnology Group. Research interests: general immunology and immunohematology, transfusiology, cell engineering, hybridoma technologies, monoclonal antibodies. Main achievements: obtaining monoclonal antibodies to human differentiation antigens by hybrid producers, development of methods for predicting type 1 diabetes mellitus, creation of a set of human monoclonal antibodies for determining blood groups and wide phenotyping of erythrocytes. Publications: elibrary.ru.
O.B. Semina — medical laboratory technician
N. A. Klimova — medical laboratory technician
Laboratory staff at work
Determination of phenotyped erythrocytes and combination of erythrocytes and platelets before transfusion to the patient
