Head of the department- orthopedic traumatologist, Vladimir Y. Zorenko, Doctor of Medical Sciences.

In 1988, Professor Y.N. Andreev, an honored scientist, established a reconstructive and restorative Department of Orthopedics at the Institute. Under the leadership of Y.N. Andreev (from 1988 to 2005), a highly professional school of surgeons was formed, which substantiated the most important provisions of hematological traumatology and orthopedics. For the first time in our country, surgeries for prosthetics of large joints began to be performed in patients with hemophilia and other blood clotting diseases.

In 2009, Doctor of Medical Sciences, Professor, doctor of the highest category, Vladimir Y. Zorenko, became head of the department.

Since 1995, the department has regularly conducted clinical trials of drugs used to treat hemophilia and other coagulopathies.

The head of the day hospital is hematologist, Vitaly D. Latyshev.

The department was established in April 2022 and functions as part of the Division of Orphan Diseases. The main focus of work is the diagnosis and treatment of congenital and acquired non-tumor pathology of the blood system, rare diseases.

The department performs diagnostics and treatment of diseases such as:

• hereditary hemolytic anemia (including beta-thalassemia, sickle cell anemia and other congenital hemoglobinopathies and membranopathies);
• autoimmune hemolytic anemia;
• paroxysmal nocturnal hemoglobinuria;
• hereditary and acquired hemochromatoses;
• histiocytosis from Langerhans cells and other rare histiocytoses (xanthogranuloma, Erdheim—Chester disease);
• systemic mastocytosis;
• congenital and acquired cytopenic syndromes;
• immune thrombocytopenia (resistant forms).

Close interaction with the round-the-clock hospital of the Department of Orphan Diseases allows us to maintain continuity in therapy and subsequent dispensary observation of patients after the inpatient treatment stage. The main focus of the department is to improve the methods of diagnosis and treatment of non-tumor diseases of the blood system, as well as the introduction of new treatment methods into clinical practice. The department conducts Russian and international clinical trials of new drugs and methods of treatment of patients with orphan diseases.

The head of the laboratory is doctor/laboratory geneticist, Tatiana N. Obukhova, Candidate of Medical Sciences.

The Laboratory of Karyology was established at the Hematological Research Center of the Russian Academy of Medical Sciences, headed by Academician Andrei I. Vorobyov, in 1988 for the practical implementation of cytogenetic research methods in clinical hematological practice, first on the scale of the NMRC for Hematology, and then throughout the country. The ideological inspirer of the organization of the laboratory was the outstanding Russian hematologist Marina Davydovna Brilliant. The first head of the laboratory (1988- 2013) was Professor Elena V. Domracheva. Since 2013, the laboratory has been headed by T. N. Obukhova.

The main focus of the Laboratory of Karyology is the study of the genetic structure of tumor diseases of the blood system - the determination of the main molecular cytogenetic events underlying the initiation and progression of tumors, as well as the development and improvement of methods for the molecular cytogenetic diagnosis of leukemia and lymphomas with the goal of identifying diagnostic chromosomal markers and cytogenetic disease prognosis factors for the selection of differentiated therapy and evaluation of the treatment effectiveness.

The laboratory specializes in cytogenetic and molecular cytogenetic diagnostics of acute leukemia, myelodysplastic syndromes, chronic myeloid leukemia and other myeloproliferative diseases, chronic lymphocytic leukemia, lymphomas, multiple myeloma, and myeloid and lymphatic tumors occurring with eosinophilia. In methods of standard cytogenetic study (karyotyping) and molecular cytogenetic study (fluorescent in situ hybridization - FISH) of bone marrow cells and peripheral blood, tumor biopsy specimens are used. FISH is also performed on archival material: paraffin blocks and biopsy prints, bone marrow and blood smears. In addition, high-resolution methods for identifying complex structural rearrangements with multicolored coloration of chromosomes are used - M-FISH and M-BAND. Patients with aplastic anemia, myelodysplastic syndromes and acute leukemias are subjected to a diepoxybutane test (DEB test) to detect chromosomal instability and Fanconi anemia. In the framework of scientific research, a modern high-resolution molecular cytogenetic method is used – comparative genomic hybridization on DNA microarrays (comparative genomic hybridization, arrayCGH) in order to identify hidden chromosomal aberrations and determine prognostically significant markers of oncohematological diseases.

The head of the department is pathologist Alla M. Kovrigina, Doctor of Biological Sciences

The main areas of work of the Department of Pathology are the diagnosis of tumor and non- tumor diseases of lymphoid tissue and the blood system based on the study of bone marrow trephine biopsies and biopsy material of the lymph nodes, obligate hematopoietic organs, and lymphoid tissues of other localizations using histological, histochemical, immunohistochemical, in situ hybridization research methods. The department performs the functions of the Reference Center of the Ministry of Health of the Russian Federation in the field of hematology and conducts a large amount of consultative diagnostic work on the study of biopsy material (paraffin blocks, finished preparations and biopsy/surgical material sent in 10% neutral formalin) from various cities, regions of the Russian Federation, and a number of CIS republics.

Research is carried out on the material of bone marrow trephine biopsies, biopsy material obtained from cor-biopsies, excisional and incisional biopsies of the lymph nodes, endoscopic studies (including thoracoscopy, laparoscopy), and surgical material, in particular, thoracotomies, laparotomies and splenectomies. The department provides intraoperative (urgent) histological diagnostics for biopsies of neoplasms of retroperitoneal localization, mediastinum, lungs, and lymph nodes.

The development of criteria for the complex differential diagnosis of B- and T-lymphomas, Hodgkin's lymphoma, Ph-negative myeloproliferative diseases, myelodysplastic syndromes, and hypoplastic conditions of the hematopoietic tissue are priority scientific areas for the Department of Pathology.

Galina A. Klyasova, Professor, Doctor of Medical Sciences

The division includes:

• Antimicrobial Drugs Clinical Pharmacology Group,
• The Laboratory of Microbiology.

The division was established in 2000 as the Laboratory of Clinical Bacteriology, Mycology and Antibiotic Therapy. The main goal of the division is the diagnosis of bacterial and fungal infections.

Scientific and clinical work is carried out in several areas:

Head of the laboratory - hematologist Irina V. Galtseva, Candidate of Medical Sciences.

The laboratory was organized on March 1, 2013

Immunophenotyping of cells, carried out using flow cytometry, is widely used in clinical diagnostic and scientific research. A distinctive feature of this analysis is the ability to determine the phenotype of single cells. The method is based on the use of monoclonal antibodies to differentiation antigens, the combination of which makes it possible to detect various cell populations. The collection of antigens on the cell surface is called an immunophenotype. Over the past 20 years, flow cytometry has become an integral tool in the diagnosis of various hematological diseases, in particular lymphomas, leukemias, plasma cell neoplastic diseases, paroxysmal nocturnal hemoglobinuria (APG), etc. Based on the data on the immunophenotype and the analysis of a large number of cells, flow cytometry makes it possible to find extremely rare cell subpopulations.

Head of the department- radiologist, Irina E. Kostina, Candidate of Medical Sciences

The department includes:

• Office of Magnetic Resonance Imaging;
• Office of X-ray Computed Tomography;

The department was formed in 2022 by combining Department of Radiology and Computed Tomography and the Department of Magnetic Resonance Imaging and Ultrasound Diagnostics.

The Department of Radiology at the NMRC for Hematology has been in existence since 1946. The first head of the department was Professor, Ella Novikova, who studied the features of radiological manifestations of pathology of bones and chest organs in blood diseases compared to the pathomorphological picture. From 1988 to 2012, the department was headed by Doctor of Medical Sciences, Lev N. Gotman, who developed a technique for angiographic embolization of the arteries of the spleen in hemoblastosis. During the period of his leadership, the department was re-equipped with modern X-ray diagnostic equipment, computer tomography and magnetic resonance imaging rooms, and a remote gamma therapy room. Since 2012, the department has been headed by Candidate of Medical Sciences, Irina E. Kostina.

The head of the office is Galina A. Yatsyk, radiologist, Candidate of Medical Sciences, member of the ESR, MRB RSR (Moscow Regional Branch of the Russian Society of Radiologists) , RSR (Russian Society of Radiology)

The office functions as part of the Department of Radiology.

The office was transformed from the Department of Magnetic Resonance Imaging and Ultrasound Diagnostics established on August 1, 2013, and since 2022 has been a part of the Department of Radiology.

The office carries out examinations of patients with hemoblastosis, hematopoiesis pathology, and orphan diseases. The whole range of standard studies and developed examination protocols in the NMRC for Hematology are performed by the office. MRI studies of the whole body, according to protocols to exclude hemoblastosis, to quantify iron overload of parenchymal organs, in Gaucher's disease, and abdominal organs with intravenous bolus contrast enhancement, including primovist are carried out. Office employees participate in the performance of state tasks and scientific activities and are experienced at operating modern equipment: Philips Ingenia magnetic resonance tomograph with 1.5 tesla magnetic field induction.

The office is headed by doctor-endoscopist,  Vladimir A. Makhinya.

The office is part of the Department of Endoscopy and Office of Ultrasound and Functional Diagnostics.

In the 70s, an endoscopic service was organized as a part of the Department of Surgery under the leadership of Prof. V.A. Klimansky. At that time, doctors like A.V. Tochenov, V.S. Shavlokhov, and I.A. Zagrekov actively worked on mastering this new method for the whole of the country, although endoscopic examinations were still quite rare. Since 2002, with the arrival of doctors V.A. Makhinya and O.Y. Popova, endoscopic examinations have become commonplace. Diagnostic capabilities have expanded and X-ray endoscopic diagnostic methods are now actively used: retrograde cholangiography, bronchography. In close cooperation with the Intensive Care Unit, under the guidance of G.M. Galstyan, methods for performing bronchoalveolar lavages were developed and improved for the diagnosis of pneumonia. In cooperation with the doctors of the Department of Anesthesiology, the technique of endoscopic application of gastrostomy was mastered. New (physical) methods of hemostasis have been introduced and are actively used - argon plasma coagulation. Currently, endosonographic methods for diagnosing diseases of the upper digestive system are being mastered. Great importance is given to the processing of endoscopes. In 2011, the Endoscopy Service became the Department of Endoscopy.

KEY EMPLOYEES

Nina V. Kislova - senior nurse. In 1984 she graduated from the Temnikovskoe Medical College with a red diploma in the specialty "paramedic.”

The head of the laboratory is psychiatrist, Dmitry E. Vybornykh, Doctor of Medical Sciences.

Since 2000, the NMRC for Hematology has been actively working on the study of mental disorders in patients of the Center, both in the study of diseases associated with the somatogenic or nosogenic influence of hematological pathology, and those unrelated to it, as well as the development of therapeutic methods for such disorders. Representatives of the Center participate in domestic and foreign conferences devoted to the issues of psycho- oncology and psycho-hematology and regularly publish papers in domestic and foreign publications.

In 2012, the NMRC for Hematology created a special group for the study of mental disorders in diseases of the blood system. This group was reorganized in 2016 into the Laboratory for the Study of Mental and Neurological Disorders in Diseases of the Blood System. The laboratory is designed to conduct systematic research in this area, which is of great scientific and applied importance.

Among the main research areas of the department: