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Research and Development Topics
STATE ASSIGNMENT Study of molecular-genetic and immunomorphological bases of clonal diseases of the blood system in order to improve diagnosis and identify prognostic factors for optimizing differential therapy Study of the possibility of using hematopoietic alloantigens as targets of cellular immunotherapy of hemoblastoses Implementation of molecular-genetic and biological mechanisms in the human body in normal and in diseases of the blood system Improvement of various stages of allogeneic and autologous hematopoietic stem cell transplantation and the development of new approaches to prevention and therapy of post-transplantation complications Optimization of the program of diagnosis, treatment and monitoring of non-tumor orphan diseases of the blood system in adults based on molecular-genetic, biochemical, and immunophenotypic parameters Optimization of programmatic hemoblastosis chemotherapy based on patient-specific biological markers of the disease Development of diagnostic reagent kits for molecular-genetic detection of oncogenic transcripts for the purpose of early diagnosis and monitoring of minimal residual disease in acute leukemia Influence of architectural and structural changes of new polymer compounds on their hemocompatibility and provision of hemostatic reactions in in vivo and in vitro experiments INITIATIVE TOPICS Study of mutations in the genes of human herpes viruses, potentially leading to resistance to antiviral drugs, in patients with hemoblastosis New approaches to the diagnosis, prevention and treatment of thrombotic and hemorrhagic complications in critically important types of hemostasis pathology Creation of a system for the comprehensive assessment of the immune response to the SARS-CoV-2 virus: identification of class G immunoglobulins and T cells that recognize viral antigens STATE ASSIGNMENT Study of molecular-genetic and immunomorphological bases of clonal diseases of the blood system in order to improve diagnosis and identify prognostic factors for optimizing differential therapy Study of the possibility of using hematopoietic alloantigens as targets of cellular immunotherapy of hemoblastoses Implementation of molecular-genetic and biological mechanisms in the human body in normal and in diseases of the blood system Development of a unified risk-adapted strategy for transplantation of allogeneic hematopoietic stem cells, combining the stages of pretransplantation conditioning, prevention of GVHD and posttransplantation patient-oriented exposure Study of the molecular genetic mechanisms of resistance and pathogenicity in nosocomial bacteria and fungi in hematology and the features of the new coronavirus infection caused by COVID-19 among patients with diseases of the blood system, in donors of blood and its components, and hematopoietic stem cells Optimization of diagnostics, treatment and monitoring of non-tumor diseases of the blood system in adults based on molecular-genetic, immunophenotypic and biological parameters Influence of architectural and structural changes of new polymer compounds on their hemocompatibility and provision of hemostatic reactions in in vivo and in vitro experiments INITIATIVE TOPICS Study of mutations in the genes of human herpes viruses, potentially leading to resistance to antiviral drugs, in patients with hemoblastosis New approaches to the diagnosis, prevention and treatment of thrombotic and hemorrhagic complications in critically important types of hemostasis pathology STATE ASSIGNMENT Study of molecular-genetic and immunomorphological bases of clonal diseases of the blood system in order to improve diagnosis and identify prognostic factors for optimizing differential therapy Study of the possibility of using hematopoietic alloantigens as targets of cellular immunotherapy of hemoblastoses The effect of chemotherapeutic drugs on the stromal microenvironment of the bone marrow in patients with hemoblastosis Implementation of molecular-genetic and biological mechanisms in the human body in normal and in diseases of the blood system Development of a unified risk-adapted strategy for transplantation of allogeneic hematopoietic stem cells, combining the stages of pretransplantation conditioning, prevention of GVHD and posttransplantation patient-oriented exposure Study of the molecular genetic mechanisms of resistance and pathogenicity in nosocomial bacteria and fungi in hematology and the features of the new coronavirus infection caused by COVID-19 among patients with diseases of the blood system, in donors of blood and its components, and hematopoietic stem cells Optimization of diagnostics, treatment and monitoring of non-tumor diseases of the blood system in adults based on molecular-genetic, immunophenotypic and biological parameters Influence of architectural and structural changes of new polymer compounds on their hemocompatibility and provision of hemostatic reactions in in vivo and in vitro experiments INITIATIVE TOPICS Study of mutations in the genes of human herpes viruses, potentially leading to resistance to antiviral drugs, in patients with hemoblastosis New approaches to the diagnosis, prevention and treatment of thrombotic and hemorrhagic complications in critically important types of hemostasis pathology Improving the methods of diagnosis and treatment of thrombotic thrombocytopenic purpura - Patients
