Head of the Laboratory of Hematopoiesis Physiology
Doctor of Biological Sciences (1990)
Specializes in the field of physiology and experimental hematology
Nina Drize graduated with honors from the Faculty of Biology of Lomonosov Moscow State University (1975).
Her scientific work is devoted to hematopoietic and stromal stem cells and biotechnology.
She belongs to the scientific school of I. L. Chertkov.
From 1977 to 1980, Nina Drize worked on her thesis for the degree of Candidate of Medical Sciences in the specialty "histology and embryology.” This work was completed at the Department of Histology and Cytology, Faculty of Biology, Lomonosov Moscow State University. The topic of the work: "Localization of Blood Germ in Ontogenesis of Chicken and Quail Embryos.”
From 1982-1990 - work on her doctoral dissertation in the specialty, "hematology and blood transfusion.” The work was completed at the Hematological Science Center (now NMRC for Hematology). Thesis topic: "Hematopoietic and Stromal Progenitor Cells in Long-term Bone Marrow Culture"
From 1980-1987 - researcher of the Laboratory of Hematopoiesis Physiology at the Hematological Scientific Center (now NMRC for Hematology)
In 1987-1997 - senior researcher of the Laboratory of Hematopoietic Physiology at the Hematological Scientific Center (NMRC for Hematology)
She has been in charge of the Laboratory of Hematopoiesis Physiology since 1997
Professional and scientific interests:
- human and rabbit mesenchymal stem cells;
- the effect of parathyroid hormone on hematopoietic stem cells and the stroma of hematopoietic organs;
- clonal succession of hematopoietic progenitor cells in vivo;
- study of hematopoietic and stromal progenitor cells in mice deficient in tumor necrosis factor;
- hematopoietic and mesenchymal progenitor cells in long-term bone marrow culture of mice;
- self-maintenance of hematopoietic stem cells and clonality of hematopoiesis in long-term cultures of mouse bone marrow;
- modulation of hematopoiesis in long-term cultures of human bone marrow with various components of the extracellular matrix;
- stem cell labeling using retroviral gene transfer;
- oncogene transduction in human and murine cell lines;
- marking of mesenchymal stromal progenitors using retroviral gene transfer;
- transduction of foreign genes into hematopoietic stem cells using electroporation;
- mobilization of hematopoietic stem cells using various growth factors;
- the origin of stromal progenitors in chimeras;
- obtaining monoclonal antibodies to erythrocyte group antigens;
- study of myeloid differentiation in DMSO-induced cell lines;
- introduction of yeast mRNA into tumor cell lines.
Nina L. Drize - Expert of the Russian Foundation for Basic Research. Member of the scientific societies ASH, ISEH, EHA.
She has defended 5 state patents.
