Head of the laboratory- Georgy T. Guria, Professor, Doctor of Physical and Mathematical Sciences
Our team consists of the researchers, working along with Prof. Georgy Guria on the study of the role of instabilities in the dynamics of complex systems, including biological regulation.
It is generally accepted that the loss of stability of any regime is a prologue to the transition of that nonequilibrium system to another state having a different time or space-time ordering. The study of different types of such non-equilibrium transitions observed in the physico-chemical and biological systems, and the task of revealing the conditions for the implementation of such transitions is the main subject of research for our team.
At the moment, obviously the most attention is given to transitions manifested in the dynamics of such sophisticated physiological substance as blood [Thrombosis Research, 2015; Guria, 2011]. In the center of our attention are both theoretical issues of finding conditions of loss of the liquid state stability of the blood and questions concerning the development of tools and methods for real-time monitoring of aggregate state of blood in vitro and in vivo [Scientific Reports, 2016; PLOS ONE, 2015; JTB, 2012; PLOS ONE, 2019; PhilosTrans, 2008]. The laboratory team uses and enhances the research approach in silico, aimed at the task of personalized assessment of thrombosis risks through the use of modern computer simulation methods (more on www.in-silico.ru).
Recently, particular attention is being paid to finding opportunities of a fast-reacting medical interference during the fastest flowing phase of intravascular thrombosis. [a href="https://doi.org/10.1371/journal.pone.0211646"; target="_blank" title="Ivlev D.A., Shirinli Sh.N., Guria K.G., Uzlova S.G. and Guria G.Th. Control of fibrinolytic drug injection via real-time ultrasonic monitoring of blood coagulation // PLOS ONE. 2019; 14(2):e0211646.">PLOS ONE, 2019; PhilosTrans, 2008].
The range of actively studied systems is not limited to the blood coagulation system. Among the actively studied issues are mass transfer processes in the human body and the work of the cellular signaling system.
PROJECTS
We are using ultrasound technique for the study of coagulation and fibrinolysis phenomena in our original experimental set-up. In particular this set-up allows us to analyze the physiological effect of the existing pharmaceutical drugs.
Research in this scientific area was supported by grants from the Russian Foundation for Basic Research:
- No. 14-04-01193 (2014-2016), "Study of the influence of the conditions of thrombus formation on its resistance to the action of fibrinolytic agents";
- No. 07-04-01523-a (2007-2009), "Study of spontaneous thrombosis in intensive flows";
- No. 04-04-49423-a (2004-2006), "Acoustic effects during blood clotting in intensive flows".
A detailed description of the experimental setup, the materials and methods used can be found in the article: [Uzlova et al., Acoustic determination of the early stages of intravascular coagulation // Filostrans, 2008].
Another research direction is the development of unique software and hardware complex, allowing to build personalized maps of potential thrombogenic danger for different areas of cardiovascular system of individual patients, and also to produce video material, which illustrates possible activation scenarios of intravascular coagulation processes. Creation of maps of potential thrombogenic danger will open new possibilities not only for doctors but also for patients to evaluate a priori, more fully and deeply the structure of the actual risks of the development of extremely dangerous pathologies associated with cardiac and circulation disorders. Illustrative video materials are available in the section Videos and on the website www.in-silico.ru., which demonstrates the possibilities of mathematical modeling of systemic hemodynamics, taking into account the phenomena of intravascular thrombosis. The project aims to expand the possibilities of personalized medicine through the use of modern computer modeling methods (within the framework of the in silico approach). A web service designed to predict personalized risks of thrombotic complications and to identify areas of increased thrombogenic danger is being developed.
This area of research has received financial support through a number of grants:
- Grant of the Russian Scientific Foundation No. 19-11-00260 (2019-2021), " Investigation of thrombogenesis activation in intensive blood flow ";
- Grant of the Russian Scientific Foundation No. 14-14-00990 (2014-2016), " Mathematical modeling of blood coagulation phenomena in human cardiovascular system ";
- Grant of the International Scientific and Technical Center No. 3744 (2007-2010), "Numerical modeling of blood flow and clotting phenomena in the human cardiovascular system";
- grants from the Russian Foundation for Basic Research: No. 99-04-48759-a (1999-2001), "The role of instabilities in blood dynamics"; No. 99-01-01145-a (1999-2001), "Mathematical modeling of thrombosis in vessels of complex geometry using models of non-Newtonian fluids"; No. 96-01-01306 (1996-1997), "Numerical study of nonequilibrium dissipative structures in models thrombosis".
Currently, the novel research approach known as in silico is actively being developed by scientists and clinicians.
PUBLICATIONS:
The laboratory staff has prepared over 50 publications in domestic and foreign scientific publications (full list of publications): The most significant publications in recent years:
Salikhova T.Y., Pushin D.M., Nesterenko I.V., Biryukova L.S. and Guria G.Th.
Patient specific approach to analysis of shear-induced platelet activation in haemodialysis arteriovenous fistula // PLOS ONE. 2022; 17(10):e0272342. doi:10.1371/journal.pone.0272342.
Abstract
I.A. Romanetz, G.Th. Guria
Certificate of state registration of the computer program No. 2022614698. Program for the analysis and classification of the topology of wavelet scalograms built for the electrocardiographic signal / Application No. 2022610846. Received on January 24, 2022. Registered in the Register of Computer Programs on March 24, 2022.
Annotation on www.fips.ru
T. Salikhova, D.M. Pushin, G.Th. Guria
Certificate of state registration of the computer program No. 2022611543. Program for computation the level of hydrodynamic activation of platelets in intensive blood flows /Application No. 2021669908. Received on December 3, 2021. Registered in the Register of Computer Programs on January 26, 2022
Annotation on www.fips.ru
Ширинли Ш.Н., Приходько И.В., Ивлев Д.А., Узлова С.Г., Гурия Г.Т.
Свидетельство о государственной регистрации программы для ЭВМ № 2022611526. Средство восстановления геометрии сосудистого русла на основании данных ультразвукового допплеровского сканирования / Ш.Н. Ширинли, И.В. Приходько, Д.А. Ивлев, С.Г. Узлова, Г.Т. Гурия – Заявка № 2021669887. Дата поступления 3 декабря 2021 г. Зарегистрировано в Реестре программ для ЭВМ 26 января 2022 г.
Annotation on www.fips.ru
Sh.N. Shirinli, I.V. Prikhodko, D.A. Ivlev, S.G. Uzlova, G.Th. Guria
Certificate of state registration of the computer program No. 2022611526. A tool for reconstructing the geometry of the vascular bed based on the data of ultrasonic Doppler scanning / Application No. 2021669887. Received on December 3, 2021. Registered in the Register of Computer Programs on January 26, 2022.
Annotation on www.fips.ru
Prikhodko I.V., Guria G.Th.
Dynamic Effects in Nucleation of Receptor Clusters // Entropy. 2021; 23(10):1245. doi:10.3390/e23101245.
Abstract
Pushin D.M., Salikhova T.Y., Zlobina K.E. and Guria G.Th.
Platelet activation via dynamic conformational changes of von Willebrand factor under shear // PLOS ONE. 2020; 15(6):e0234501. doi:10.1371/journal.pone.0234501.
Abstract
Sapega T.S., Guria G.Th.
Stability Analysis of PI3K-Akt-mTOR Intracellular Signaling Pathway // Biophysics. 2020; 65(2):259–267. doi: 10.1134/S0006350920020207.
Abstract
Перевод статьи [Сапега Т.С., Гурия Г.Т. Биофизика. 2020; 65(2):300-309] на английский язык:
Sapega T.S., Guria G.Th. Stability Analysis of PI3K-Akt-mTOR Intracellular Signaling Pathway // Biophysics. 2020; 65(2):259–267. doi: 10.1134/S0006350920020207.
Ivlev D.A., Shirinli Sh.N., Guria K.G., Uzlova S.G. and Guria G.Th.
Control of fibrinolytic drug injection via real-time ultrasonic monitoring of blood coagulation // PLOS ONE. 2019; 14(2):e0211646. doi:10.1371/journal.pone.0211646.
Abstract
Ivlev D.A., Shirinli Sh.N., Uzlova S.G., Guria K.G.
Ultrasonic monitoring of coagulation and fibrinolysis in intensive blood flows // Biophysics. 2018; 63(4):637-643. doi: 10.1134/S0006350918040085.
Abstract
Перевод статьи [Ивлев Д.А. с соавт. Биофизика. 2018; 63(4):803-811] на английский язык:
Ivlev D.A., Shirinli Sh.N., Uzlova S.G., Guria K.G. Ultrasonic monitoring of coagulation and fibrinolysis in intensive blood flows // Biophysics. 2018; 63(4):637-643. doi: 10.1134/S0006350918040085.
Rukhlenko O.S., Guria G.T., Vorobiev A.I.
On the chemotherapeutic agents localization in tissue by means of snake venoms // Medical Hypotheses. 2017; 104:89-92. doi:10.1016/j.mehy.2017.05.025.
Abstract
Zlobina K.E., Guria G.Th.
Platelet activation risk index as a prognostic thrombosis indicator // Scientific Reports. 2016; 6:30508. doi:10.1038/srep30508.
Abstract
FINANCING
The laboratory's research has received financial support from grants from the Russian Foundation for Basic Research (RFBR), the International Scientific and Technical Center (ISTC) and the Russian Science Foundation (RSF).
SCIENTIFIC CONTACTS
Prof. Sergey Strelkov
Catholic University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Biocrystallography
Belgium
Prof. Miguel Herrera
Complutense University, Faculty of Mathematical Sciences
Spain, Madrid
Prof. Werner Ebeling
Humboldt University of Berlin, Faculty of Physics, Statistical Physics and Nonlinear Dynamics
Germany, Berlin
Dr. Jorn Schmelzer
Rostock University, Faculty of Physics
Germany, Rostock
Prof. Maxim Davidovich Frank-Kamenetsky
Boston University
USA, Massachusetts
Vacancies for students and postgraduates
The laboratory currently has vacancies for undergraduates and postgraduates.
Detailed information:
Head of the laboratory, Professor, Doctor of Physical-Mathematical Sciences, Gregory T.
Guria: guria@blood.ru
STAFF
Svetlana G. Uzlova — Senior Researcher, Candidate of Biological Sciences
Ilya A. Romanets — Researcher, Candidate of Biological Sciences
Dmitry A. Ivlev — researcher, Candidate of Physical-Mathematical Sciences
Denis M. Pushin — researcher
Alexander S. Gorbatenko — researcher
Tatiana Y. Salikhova- trainee researcher
Ilya A. Ponomarev- specialist
Ivan V. Prikhodko- trainee researcher
Mikhail Y. Oliferenko — senior laboratory assistant
